Laboratory of Marine Drug Discovery

 [Recent]

• Regioselective synthesis of the FXR antagonist E-Guggulsterone from three natural steroids. Bull. Korean Chem. Soc., 2017. 38(5): p 525-529. (Corresponding author)

• Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490. Mar Drugs, 2017. 15(8). (Corresponding author)

• Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja. Bioorganic & Medicinal Chemistry Letters, 2017. 27(3): p. 574-577. (Corresponding author)

• Acredinone C and the Effect of Acredinones on Osteoclastogenic and Osteoblastogenic Activity. Journal of Natural Products, 2016. 79(7): p. 1730-1736. (Corresponding author)

• The Halicylindramides, Farnesoid X Receptor Antagonizing Depsipeptides from a Petrosia sp Marine Sponge Collected in Korea. Journal of Natural Products, 2016. 79(3): p. 499-506. (Corresponding author)

• Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae. Tetrahedron Letters, 2016. 57(18): p. 1997-2000. (Corresponding author)

• Acredinones A and B, Voltage-Dependent Potassium Channel Inhibitors from the Sponge-Derived Fungus Acremonium sp. F9A015, J. Nat. Prod, 2015, 78, 363-367 (Corresponding author)

• Anithiactins A-C, Modified 2-Phenylthiazoles from a Mudflat-derived Streptomyces sp. J. Nat. Prod, 2014, 77, 2716-2719 (Corresponding author)

• Monanchosterols A and B, Bioactive Bicyclo[4.3.1]steroids from a Korean Sponge Monanchora sp. J. Nat. Prod 2014, 27, 368-373(Corresponding author)

• Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp. Arch. Pharm. Res. 2014, 38, 18-25 (Corresponding author)

• An Antibacterial 9,11-Secosterol from a Marine Sponge Ircinia sp. Bull Korean Chem Soc, 2014, 35, 3360-3362 (Corresponding author)

• Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp. Tetrahedron Lett. 2014, 55, 4716-4719 (Corresponding author)

• Phorbaketals L–N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas, Bioorg. Med. Chem. Lett. 2014, 24, 4095-4098 (Corresponding author)

• Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp. Mar Drugs, 2014, 77, 1528-1531 (Corresponding author)

• Anmindenols A and B, Inducible Nitric Oxide Synthase Inhibitors from a Marine-Derived Streptomyces sp. J. Nat. Prod. 2014, 77, 1528-1531 (Corresponding author)

• Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp. Bioorg. Med. Chem. Lett. 2013, 23, 2336-2339 (Corresponding author)

• Bioactive Sesterterpenoids from a Korean Sponge Monanchora sp. J. Nat. Prod. 2013, 76, 170-177 (Corresponding author)

• Phosphoiodyns A and B, Unique Phosphorus-Containing Iodinated Polyacetylenes from a Korean Sponge Placospongia sp. Org. Lett. 2013, 15, 100-103 (Corresponding author)

[1996 ~ 2012]

• ADEQUATE, a new set of experiments to determine the constitution of small molecules at natural abundance, J. Magn. Reson. 1996, 118, 282-285 (co-author)

• New isoeudistomin class dihydro-B- carbolines from an undescribed ascidian of the genus Eudistoma, Nat Prod Lett 1996, 9, 7-12 (Co-author)

• Isolation of microbial antibiotics from a marine ascidian of the genus Didemnum, J. Org. Chem. 1996, 61, 1543-1546 (Co-author)

• Polycarpine dihydrochloride: a cytotoxic dimeric disulfide alkaloid from the Indian ocean ascidian Polycarpa clavata, Tetrahedron Lett. 1996, 37, 2369-2372 (Co-author)

• Aplidiamine, a unique zwitterionic benzyl hydroxyadenine from the western Australian marine ascidian aplidiopsis sp, Tetrahedron Lett. 1997, 38, 941-944 (Co-author)

• Ningalins A-D : novel aromatic alkaloids from a western Australian ascidian of the genus Didemnum,  J. Org. Chem. 1997, 62, 3254-3262 (Co-author)

• BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites, Genes Dev 1998, 12, 1269- 1277 (Co-author)

• Dectection of antifungal activity in Belamcanda chinensis by a single-cell bioassay method and isolation of its active compound, tectorigenin, Biosci. Biotechnol. Biochem. 2001, 65, 939- 942 (Co-author)

• Ca2+/Calmodulin- Dependent Protein Kinase IV Stimulates Nuclear Factor-kB Transactivation via Phosphorylation of the p65 Subunit, J. Biol. Chem. 2001, 276, 20005-20010 (Co-author)

• Interactions among the toxic dinoflagellate Amphidinium carterae, the geterotrophic dinoflagellate oxyrrhis marina and the calanoid copepods acartia spp, Mar. Ecol. Prog. Ser. 2001, 218, 77-86 (Co-author)

• The Orphan Nuclear receptor SHP, as a novel coregulator of nuclear factor-kB in oxLDL-treated macrophage cell RAW 264.7, J. Biol. Chem. 2001, 276, 33736-33740 (Co-author)

• Efficient syntheses of 2-Carbomethoxy-3, 4-Disubstituted Pyrroles by the Condensation of vinylogous amides with aminomalonate, Bull Korean Chem Soc, 2001, 22, 1403-1406 (Co-author)

• A novel cytotoxic alkaloid of lamellarin class from a marine ascidian didemnum sp, Bull Korean Chem Soc, 2002, 23, 163-166 (Co-author)

• Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90, Mol. Cell. Endocrinol. 2002, 188, 47-54 (Co-author)

• Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism, Bioorg. Med. Chem. Lett. 2002, 12, 895-898 (Co-author)

• FOR, a novel orphan nuclear receptor related to FXR, J. Biol. Chem. 2002, 277, 17836-17844 (Co-author)

• Expression of Sortase, a Transpeptidase for Cell Wall Sorting Reaction, from Staphylococcus aureus ATCC 6538p in Escherichia coli, J Microbiol Biotechnol Res, 2002, 12, 530-533 (Co-author)

• PPARδ is very low-density lipoprotein sensor in macrophages, Proc. Natl. Acad. Sci. U.S.A 2003, 100, 1268-1273 (Co-author)

• Reduction in the toxicity caused by a toxic dinoflagellate Gymnodinium catenatum by the feeding of the heterotrophic dinoflagellate Polykrikos kofoidii, Aquat. Microb. Ecol. 2003, 31, 307-312 (Co-author)

• Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity, Cell 2003, 113, 159-170 (Co-author)

• Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice, Mol. Cell. Biol 2003, 23, 3583-3592 (Co-author)

• Facile one-pot synthesis of alkyl aryl sulfides from aryl bromides, J. Org. Chem. 2004, 69, 3236-3239 (Co-author)

• Regulation of muscle fiber type and running endurance by PPARδ, PLoS Biol. 2004, 2, 1532-1539 (Co-author)

• Activated liver X receptors stimulate adipocyte differentiation through induction of PPARγ expression, Mol. Cell. Biol. 2005, 24, 3430-3444 (Co-author)

• A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor δ through in situ protection of phenol with a grignard reagent, Tetrahedron Lett. 2005, 46, 6683-6686 (Corresponding author)

• An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ, Nucleic Acids Res. 2005, 33, 6756-6768 (Corresponding author)

• PPAR delta regulates glucose metabolism and insulin sensitivity, Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 3444-3449 (Co-author)

• A Facile One-Pot Preparation of Alkyl Aminoaryl Sulfides for the Synthesis of GW7647 as an Agonist of Peroxisome Proliferator-Activated Receptor α, J. Org. Chem. 2006, 71, 5781-5784 (Corresponding author)

• A simple one-pot synthesis of hydroxylated and carboxylated aryl alkyl sulfides from various bromobenzenes, Tetrahedron Lett. 2006, 47, 7101-7106 (Corresponding author)

• Farnesoid X-activated receptor antagonists from a marine sponge Spongia sp. Bioorg. Med. Chem. Lett. 2006, 16, 5398-5402 (Corresponding author)

• Scalarane Sesterpenes From a Marine Sponge of the Genus Spongia and Their FXR Antagonistic Activity, J. Nat. Prod. 2008, 70, 1691-1695 (Co-author)

• Cooperation and Functional Diversification of Two Closely Related Galactolipase Gene for Jasmonate Biosynthesis, Dev. Cell, 2008, 14, 183-192 (Corresponding author)

• B-Carboline Alkaloid From A Korean Tunicate Eudistoma Sp. J. Nat. Prod. 2008, 71, 163-166 (Corresponding author)

• PPARδ regulates multiple pro-inflammatory pathways to suppress atherosclerosis, Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 4271-4276 (Co-author)

• A Facile One-Pot Preparation of Potassium Hydroxyl-and (Hydroxyalkyl)asyltrifluoroborates, Org. Lett. 2008, 10, 1215-1218 (Corresponding author)

• Cyanopeptoline CB071:A Cyclic Depsipeptide Isolated from the Freshwater Cyanobacterium Aphanocapsa sp, Chem. Pharm. Bull. 2008, 54 1191-1193 (Corresponding author)

• AMPK and PPARδ Agonists Are Exercise Mimetics, Cell, 2008, 134(4), 405-415 (Co-author)

• A Facile One-Pot Preparation of Organoselanyltrifluoroborates from Dihalobenzenes and Their Cross-Coupling Reaction, Org. Lett. 2009, 11, 361-364 (Corresponding author)

• One-Pot Synthesis of Alkyl Aryl Selenides with Hydroxy-, Amino-, and Carboxy-Functionality from Aryl Halides, Bull Korean Chem Soc, 2009, 2, 496-498 (Corresponding author)

• Isoplatensimycin: Synthesis and biological evaluation, Bioorg. Med. Chem. Lett., 2009, 19, 4601-4602 (Co-author)

• A receptor-independent, cell-based JAK activationa assay for screening for JAK3-specific inhibitors, Journal of Immunological Methods, 2010, 354, 45-52 (Corresponding author)

• A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactone and its PPAR activities, Bioorg. Med. Chem. Lett. 2010, 20, 6017-6019 (Corresponding author)

• Selective peroxisome proliferator-activated receptor d isosteric selenium agonists as potent anti-atherogenic agents in vivo, Bioorg. Med. Chem. Lett. 2010, 20, 7239-7242 (Corresponding author)

• 7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: More potent analogs of platensimycin, Bioorg. Med. Chem. Lett. 2010, 20, 2156-2158 (Co-author)

• Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge Phorbas gukulensis, J. Nat. Prod. 2010, 73, 734-737 (Co-author)

• Tuberatolides, Potent FXR Antagonists from the Korean Marine Tunicate Botryllus tuberatus, J. Nat. Prod. 2011, 74, 90-94 (Corresponding author)

• A Regioselective Synthesis of E-Guggulsterone, Molecules, 2011, 2, 4165-4171 (Corresponding author)

• Synthesis of an Urea-substituted Selenoisobutyric Acid Isostere of the Peroxisome Proliferator-activated Receptor α Selective Agonist, Bulletin of the Korean Chemical Society, 2011, 32, 4089-4091 (Corresponding author)

• Synthesis of an Unnatural Steroid as a Farnesoid X Receptor Antagonist, Bulletin of the Korean Chemical Society, 2011, 32, 4165-4166 (Corresponding author)

• Sterols from a Soft Coral, Dendronephthya gigantea as Farnesoid X-activated receptor antagonists, Steroids, 2012, 77, 355-359 (Corresponding author)

• Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor d agonists as potent anti-obesity agents in vivo, Eur J Med Chem, 2012, 53, 190-202 (Corresponding author)

• Phorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp. Org. Lett. 2012, 14, 4486-4489 (Corresponding author)